I recently bought a set of Kuryakyn ISO grips and they are much more comfortable than stock. The purchase and addition of the matching Contour Throttle Boss (6299) made it that much better during those long rides and allows you to loosen and relax your grip on the throttle. Furthermore, why stop there? I also purchased the left side (6309) and now both hands are equally content. I recommend this combination for maximum comfort.
I used to have a cruise control knob on the end of my grip, but I decided to change out my grips, and the cruise control wouldnt work with the new grips. I was really looking hard for something that would help save my hand from cramping up on the longer rides. This throttle boss did the trick. Not only does it provide relief for my hand and arm, it looks awesome with my ISO grips. Great product, and great price. You can never go wrong with Kuryakyn, or Dennis Kirk.